Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves
نویسندگان
چکیده
منابع مشابه
Valvular Heart Disease Prosthesis-Patient Mismatch Predicts Structural Valve Degeneration in Bioprosthetic Heart Valves
Background—Prosthesis-patient mismatch (P-PtM) after aortic valve replacement results in disturbed valve performance associated with increased pressure gradients. However, it is unknown whether this can be related to future structural valve deterioration (SVD) of the bioprosthesis. Methods and Results—In 564 patients (mean age, 74 5 years) receiving an aortic valve bioprosthesis, clinical follo...
متن کاملProsthesis-patient mismatch predicts structural valve degeneration in bioprosthetic heart valves.
BACKGROUND Prosthesis-patient mismatch (P-PtM) after aortic valve replacement results in disturbed valve performance associated with increased pressure gradients. However, it is unknown whether this can be related to future structural valve deterioration (SVD) of the bioprosthesis. METHODS AND RESULTS In 564 patients (mean age, 74+/-5 years) receiving an aortic valve bioprosthesis, clinical f...
متن کاملComparative hydrodynamic evaluation of bioprosthetic heart valves.
BACKGROUND AND AIM OF STUDY Pressure gradients across cardiac valve prostheses have been identified as one of the most important performance measures in valve replacement surgery. Specifically in aortic valves, these gradients influence reduction of left ventricular hypertrophy and are postulated to influence long-term survival. The correct choice of replacement valve is hampered by a lack of u...
متن کاملMetabolic syndrome is associated with faster degeneration of bioprosthetic valves.
BACKGROUND Several studies have reported similarities between calcification of the native aortic valve and atherosclerosis. Recent studies also suggested that hypercholesterolemia may be a risk factor for calcific degeneration of bioprosthetic valves. The metabolic syndrome (MS) is associated with a higher risk of vascular atherosclerosis. We thus hypothesized that the atherogenic features of M...
متن کاملPrevention of calcification in bioprosthetic heart valves: challenges and perspectives.
Surgical replacement with artificial devices has revolutionised the care of patients with severe valvular diseases. Mechanical valves are very durable, but require long-term anticoagulation. Bioprosthetic heart valves (BHVs), devices manufactured from glutaraldehyde-fixed animal tissues, do not need long-term anticoagulation, but their long-term durability is limited to 15 - 20 years, mainly be...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2020
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2020.06.008